Until recently, visualizing the architectural and cellular morphology of human tissue has required histopathological examination. Samples would be excised from the patient, processed, sectioned, stained and viewed under a microscope. In addition to being invasive, time consuming, and costly, the static nature of conventional pathology prohibits the study of biological dynamics and function. The Tearney Laboratory at Massachusetts General Hospital leads the way in transforming the current diagnostic paradigm through the invention and translation of new noninvasive, high-resolution optical imaging modalities that enable disease diagnosis from living patients without excising tissues from the body.
Led by Guillermo (Gary) Tearney, MD, PhD, the lab’s large multidisciplinary team invents, validates and translates novel devices that use light to conduct microscopy in living patients. Light is uniquely well suited for noninvasively interrogating the microscopic structure, molecular composition and biomechanical properties of biological tissues. The goal of the laboratory’s research is to improve understanding and diagnosis of disease by imaging the human body at the highest possible level of detail in vivo.
Coronary artery imaged with
Dysplastic Barrett's Esophagus imaged with SECM
The stomach imaged with OCT Capsule
Cilia lining the trachea imaged with µOCT
Ampulla of Vater imaged with OCT Capsule
The Tearney Lab's collaboration with the Aga Khan Univeristy brings unique imaging ‘pill’ to Karachi
“This novel technology offers a cheaper, non-invasive way to explore the genesis of childhood malnutrition and other gastrointestinal diseases,” said Dr. Asad Ali, associate dean for research and an associate professor in paediatrics and child health at AKU.
Read more about this project here
Hot off the Bench!
for seeing cells in living tissue continuously
The Tearney Lab is developing implantable microscopes that can be implanted directly into the body to monitor cells as they move and interact. This long-term, high-resolution view of cells will transform our understanding of disease and how to treat it.
Wireless Implantable Microscope (WIM)
Renal tubule cells imaged 24 hours after WIM implantation