Micro Optical Coherence Tomography (μOCT)

Cholesterol Crystal with Histology

μOCT Cholesterol Crystal

Cholesterol Crystal with Histology μOCT Cholesterol Crystal

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Micro-Optical Coherence Tomography (μOCT) is the highest resolution OCT technology available today. μOCT is being used in several areas in which its high resolution and speed make it the only technology able to image many biological phenomena.  One such example is the respiratory airways, which are normally lined with cilia, microscopic hairs that continuously work to sweep away mucus.  This process is a crucial element of respiratory defense that becomes impaired in a variety of diseases, including cystic fibrosis.  Another example is in vascular disease.  Intravascular ultrasound and conventional OCT can detect plaques in arteries, but μOCT can see the interaction between individual cells, helping to discover the factors that contribute to vulnerable plaque formation and rupture.

Clinical
Technology

Relevant Publications

  1. Liu L, Gardecki JA, Nadkarni SK, Toussaint JD, Yagi Y, Bouma BE, Tearney GJ. Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomography. Nat Med. 2011;17(8);1010-4.

  2. Liu, L., J.A. Gardecki, S.K. Nadkarni, J.D. Toussaint, Y. Yagi, B.E. Bouma, and G.J. Tearney, Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomography. Nat Med, 2011.

  3. Liu L, Chu KK, Houser GH, Diephuis BJ, Li Y, Wilsterman EJ, Shastry S, Dierksen G, Birket SE, Mazur M, Byan-Parker S, Grizzle WE, Sorscher EJ, Rowe SM,  Tearney GJ. Method for quantitative study of airway functional microanatomy using micro-optical coherence tomography. PLoS One. 2013;8(1):e54473. doi: 10.1371/journal.pone.0054473. Epub 2013 Jan 23. PubMed PMID: 23372732; PubMed Central PMCID: PMC3553101

  4.  Kashiwagi M, Liu L, Chu KK, Sun CH, Tanaka A, Gardecki JA, Tearney GJ. Feasibility of the assessment of cholesterol crystals in human macrophages using micro optical coherence tomography. Public Library of Science One, 2014 Jul 21. 9(7):e102669. PMID: 25048105; PMCID: PMC4105533.