The Tearney Lab has unlocked a new paradigm for diagnosing gastrointestinal (GI) diseases that eliminates the sampling errors associated with endoscopic biopsy – all in a simple, rapid, and inexpensive procedure. The technique, termed tethered capsule endomicroscopy (TCE), involves swallowing an optomechanically-engineered pill that obtains microscopic images of the GI tract. The results obtained from unsedated human subjects showed that three-dimensional microscopic images of the entire esophagus can be obtained in just a few minutes. After imaging, the capsule is withdrawn using the tether, disinfected, and reused.
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