Capsule Technologies

GI Capsule

GI Capsule Scale

GI Capsule with Tether

Flexable Tether

Lower Esophagus Imaged with Capsule

GI Capsule GI Capsule Scale GI Capsule with Tether Flexable Tether Lower Esophagus Imaged with Capsule

Summary

The Tearney Lab has unlocked a new paradigm for diagnosing gastrointestinal (GI) diseases that eliminates the sampling errors associated with endoscopic biopsy – all in a simple, rapid, and inexpensive procedure. The technique, termed tethered capsule endomicroscopy (TCE), involves swallowing an optomechanically-engineered pill that obtains microscopic images of the GI tract.  The results obtained from unsedated human subjects showed that three-dimensional microscopic images of the entire esophagus can be obtained in just a few minutes.  After imaging, the capsule is withdrawn using the tether, disinfected, and reused.

Media Coverage

CNN – The pill camera that’s easy to swallow

Reuters – Cancer detection as easy as popping a pill

Clinical
Technology

Relevant Publications

  1. Sauk J, Coron E, Kava L, Suter M, Gora M, Gallagher K, Rosenberg M,Ananthakrishnan A, Nishioka N, Lauwers G, Woods K, Brugge W, Forcione D, Bouma BE, Tearney G. Interobserver Agreement for the Detection of Barrett’s Esophagus with Optical Frequency Domain Imaging. Dig Dis Sci. 2013 Mar 19. [Epub ahead of print] PubMed PMID: 23508980.

  2. Gora MJ, Sauk JS, Carruth RW, Lu W, Carlton DT, Soomro A, Rosenberg M, Nishioka NS, Tearney GJ. Imaging the upper gastrointestinal tract in unsedated patients using tethered capsule endomicroscopy. Gastroenterology. 2013 Oct;145(4):723-5. doi: 10.1053/j.gastro.2013.07.053. Epub 2013 Aug 8. PubMed PMID: 23932950; PubMed Central PMCID: PMC3866798.

  3.  Tabatabaei N, Kang D, Wu T, Kim M, Carruth RW, Leung J, Sauk JS, Shreffler W, Yuan Q, Katz A, Nishioka NS, Tearney GJ. Tethered confocal endomicroscopy capsule for diagnosis and monitoring of eosinophilic esophagitis. Biomed Opt Express. 2013 Dec 13;5(1):197-207. doi: 10.1364/BOE.5.000197. eCollection 2013 Dec 13. PubMed PMID: 24466487; PubMed Central PMCID: PMC3891332.