Eosinophilic Esophagitis

Changing the standard of care for Eosinophilic Esophagitis

Changing the Standard of Care for Eosinophilic Esophagitis

Changing the standard of care for Eosinophilic Esophagitis Changing the Standard of Care for Eosinophilic Esophagitis

Changing the standard of care for Eosinophilic Esophagitis

Eosinophilic esophagitis (EoE) is a common food allergy, resulting in symptoms such as nausea, vomiting, heartburn, food impactions, and difficulty swallowing. Current standard of care requires several sedated endoscopies with biopsies to diagnose, confirm effective treatment and the elimination of eosinophils. These procedures are expensive, time consuming, and difficult for patients to tolerate.  We have shown that spectrally-encoded confocal microscopy (SECM), is capable of identifying eosinophils, and soon we hope to have a swallowable SECM capsule that is capable of performing sub-cellular imaging of the esophagus, visualizing eosinophils without sedation or use of contrast agents. We believe that an SECM tethered capsule has the potential to be a reliable and affordable tool for the diagnosis and follow up care of EoE.

 

Clinical
Technology

Relevant Publications

  1.  Tabatabaei N, Kang D, Wu T, Kim M, Carruth RW, Leung J, Sauk JS, Shreffler W, Yuan Q, Katz A, Nishioka NS, Tearney GJ. Tethered confocal endomicroscopy capsule for diagnosis and monitoring of eosinophilic esophagitis. Biomed Opt Express. 2013 Dec 13;5(1):197-207. doi: 10.1364/BOE.5.000197. eCollection 2013 Dec 13. PubMed PMID: 24466487; PubMed Central PMCID: PMC3891332.