Coronary Artery Disease

OFDI Artery with Calcium Deposit

3D Coronary OFDI

OFDI Coronary Flythrough with Stent

uOCT image of Cholesterol Crystal

uOCT Coronary Plaque with Hystology

Witnessed Coronary Plaque Rupture

OFDI Artery with Calcium Deposit 3D Coronary OFDI OFDI Coronary Flythrough with Stent uOCT image of Cholesterol Crystal uOCT Coronary Plaque with Hystology Witnessed Coronary Plaque Rupture

Seeing a Heart Attack Before it Happens

The importance of understanding coronary artery disease cannot be overstated; it is the number one cause of death in the US.  Each year half a million Americans die from heart attacks.  An equal number survive with considerable and permanent damage to their heart.

Coronary artery disease is caused by cells that are too small to visualize using modern medical imaging technologies. Our lab’s work with Micro Optical Coherence Tomography (μOCT) will change how we study, diagnose, and treat this disease by developing a new intracoronary imaging system that will allow researchers and physicians to see these cells in living human patients for the first time.

The ability to see the cell structure of a patient’s arteries will allow clinicians to diagnose and treat coronary artery disease before a heart attack occurs.

Clinical
Technology

Relevant Publications

  1. Fard AM, Vacas-Jacques P, Hamidi E, Wang H, Carruth RW, Gardecki JA, Tearney GJ. Optical coherence tomography–near infrared spectroscopy system and catheter for intravascular imaging. Opt Express. 2013 Dec 16;21(25):30849-58. doi: 10.1364/OE.21.030849. PubMed PMID: 24514658; PubMed Central PMCID: PMC3926541

  2.  Jamil Z, Tearney G, Bruining N, Sihan K, van Soest G, Ligthart J, van Domburg  R, Bouma B, Regar E. Interstudy reproducibility of the second generation, Fourier domain optical coherence tomography in patients with coronary artery disease and  comparison with intravascular ultrasound: a study applying automated contour detection. Int J Cardiovasc Imaging. 2013 Jan;29(1):39-51. doi: 10.1007/s10554-012-0067-8. PubMed PMID: 22639296; PubMed Central PMCID: PMC3550705.

  3.  Kashiwagi M, Liu L, Chu KK, Sun CH, Tanaka A, Gardecki JA, Tearney GJ. Feasibility of the assessment of cholesterol crystals in human macrophages using micro optical coherence tomography. Public Library of Science One, 2014 Jul 21. 9(7):e102669. PMID: 25048105; PMCID: PMC4105533.

  4. Ughi, G.J., J. Verjans, A.M. Fard, H. Wang, E. Osborn, T. Hara, A. Mauskapf, F.A. Jaffer, and G.J. Tearney, Dual modality intravascular optical coherence tomography (OCT) and near-infrared fluorescence (NIRF) imaging: a fully automated algorithm for the distance-calibration of NIRF signal intensity for quantitative molecular imaging. Int J Cardiovasc Imaging, 2014.

  5. Wang H, Gardecki JA, Ughi GJ, Jacques PV, Hamidi E, Tearney GJ. Ex vivo catheter-based imaging of coronary atherosclerosis using multimodality OCT and NIRAF excited at 633 nm. Biomed Opt Express. 2015;6(4):1363-75. PubMed PMID: 25909020; PubMed Central PMCID: PMCPMC4399675.

  6. Gerbaud E, Weisz G, Tanaka A, Kashiwagi M, Shimizu T, Wang L, Souza C, Bouma BE, Suter MJ, Shishkov M, Ughi GJ, Halpern EF, Rosenberg M, Waxman S, Moses JW, Mintz GS, Maehara A, Tearney GJ. Multi-laboratory inter-institute reproducibility study of IVOCT and IVUS assessments using published consensus document definitions. Eur Heart J Cardiovasc Imaging. 2016 Jul;17(7):756-64. doi: 10.1093/ehjci/jev229. Epub 2015 Sep 15. PubMed PMID: 26377904; PubMed Central PMCID: PMC4907381.